The purpose of this paper is to propose the portfolio management framework for Six Sigma projects, identifying the main stages and stakeholders. A literature review enlightens different aspects of project portfolio management. These different perspectives were brought into a Six Sigma, Project and Portfolio Integrated Framework (SSP&PIF). Further, two case studies from health care and IT sectors are presented. The empirical data are gathered from 12 interviews of selected stakeholders in companies, as well as participant observation and documentation. The framework helps to understand six sigma projects portfolio, in multiple levels simultaneously. The cases revealed the company which Six Sigma was implemented based on the project management methodology, supported by the PMO, the projects portfolio move toward a more strategic perspective. However, there were several lacks in the projects portfolio in both the studied companies.